MHC Class I Antigens In Malignant Cells
Opis: Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immunotherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy. MHC Class I Antigens In Malignant Cells jest dostępny w sprzedaży w kategorii księgarnia ( E-booki ) [ E-Beletrystyka ] w cenie 321 zł i 25 gr (trzysta dwadzieścia jeden złoych i dwadzieścia pięć groszy), Marka tego produktu jest nieznana.. Produkt jest nowy, a oferta jest dostępna na sprzedaż po kliknięciu w kup teraz lub w przycisk więcej informacji. Numer oferty : 2640077. Następna oferta to Tale of the Black Hound. Tą ofertę wyświetlono dziesięć razy.| Numer dostawcy | 44084 |
| ID | bd55c632-a9d3-4518-9185-2cce0e0c5a34 |
| Ostatnia zmiana | 1675140792161 |
| Waluta | PLN |
| Dostępność | 1 |
| Kategoria | Księgarnia/E-booki/E-Beletrystyka |
| Numer produktu | 2640077 |
| Wyświetleń | 10 |
| Oferta sklepu | Zobacz ofertę sklepu |
| Wydawnictwo | Springer New York |
| Format | |
| Autor | Natalia Aptsiauri |
| ISBN | 9781461465430 |
| Rok wydania | 2013 |
